Association of hepatitis C with insulin resistance and type 2 diabetes in US general population: the impact of the epidemic of obesity
Journal of Viral Hepatitis,
Stepanova M et al. – Although HCV infection was independently associated with an increased risk of diabetes and IR in the US population over a decade ago, assessment of the later NHANES cycles shows that this relationship may have become diluted by the rapid rise of other risks for diabetes, specifically, the prevalence of obesity.Methods
- The aim of the study is to assess the relationship between HCV positivity and insulin resistance/diabetes in the US population.
- Three cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 1988 and 2008 were used. HCV infection was diagnosed using a positive serologic anti-HCV test.
- Additionally, diabetes was diagnosed as fasting blood glucose ≥126 mg/dL and/or the use of hypoglycaemic medications.
- Insulin resistance was defined as a homeostasis of model assessment (HOMA) score of >3.0.
- Logistic regression was used to estimate the odds ratios (ORs) of each of the potential risk factors for diabetes mellitus (DM).
- The SUDAAN 10.0 was used to run descriptive and regression analyses.
- A total of 39506 individuals from three NHANES cycles (1988-1994, 1999-2004 and 2005-2008) with complete demographic and relevant clinical data were included.
- Over these three NHANES cycles, prevalence of hepatitis C did not significantly change.
- During the first NHANES cycle (1988-1994), insulin and diabetes were independently associated with hepatitis C.
- However, during the later study cycles (1998-2008), these associations were no longer significant.