Statin use and fatal prostate cancer
Cancer,  Clinical Article

Marcella SW et al. – Statin use was associated with substantial protection against prostate cancer death, adding to the epidemiologic evidence for an inhibitory effect on prostate cancer.

Methods
  • This was a matched case-control study.
  • Cases were residents of New Jersey ages 55 to 79years who died from prostate cancer between 1997 and 2000.
  • The cases were matched individually to population-based controls by 5-year age group and race.
  • Medication data were obtained identically for cases and controls from blinded medical chart review.
  • Conditional logistic regression was used to adjust for confounders.

Results
  • In total, 718 cases were identified, and cooperation was obtained from 77% of their spouses (N=553).
  • After a review of medical records, 387 men were eligible, and 380 were matched to a control.
  • The unadjusted odds ratio was 0.49 (95% confidence interval, 0.34-0.70) and decreased to 0.37 (P<.0001) after adjusting for education, waist size, body mass index, comorbidities, and antihypertensive medication.
  • There was little difference between lipophilic and hydrophilic statins, but more risk reduction was noted for high-potency statins (73%; P<.0001) compared with low-potency statins (31%; P=.32).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List