Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis

Journal of Korean Medical Science, 04/13/2012

Hong YJ et al. – Virtual histology–intravascular ultrasound analysis demonstrates that anemia at the time of clinical presentation is associated with vulnerable plaque component in patients with acute coronary syndrome.

Methods

  • The authors compared VH–IVUS findings between anemia group (171 patients, 260 lesions) and non–anemia group (569 patients, 881 lesions).
  • Anemia group had greater % necrotic core (NC) volume (21% ± 9% vs 19% ± 9%, P = 0.001) compared with non–anemia group.

Results

  • Hemoglobin level correlated negatively with absolute NC volume (r = –0.235, P < 0.001) and %NC volume (r = –0.209, P < 0.001).
  • Independent predictors of TCFA by multivariate analysis were diabetes mellitus (odds ratio [OR], 2.213; 95% confidence interval [CI], 1.403–3.612, P = 0.006), high–sensitivity C–reactive protein (OR, 1.143; 95% CI, 1.058–1.304, P = 0.012), microalbuminuria (albumin levels of 30 to 300 mg/g of creatinine) (OR, 2.124; 95% CI, 1.041–3.214, P = 0.018), and anemia (OR: 2.112; 95% CI 1.022–3.208, P = 0.028).

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