Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia

Asian Journal of Psychiatry, 03/30/2012

The cluster analysis confirmed a two–group solution that corresponded to the authors' non–schizotaxic and schizotaxic groups, but it increased the non–schizotaxic group to 135, and reduced the schizotaxic group to 53. Both schizotaxic groups, but especially the cluster–derived group, showed significant impairment in a variety of independent measures of clinical and social function. These findings provide additional validity for a liability syndrome, and for its utility as an intervention target for strategies aimed at ameliorating both its core and its associated symptoms.

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