Pathogenesis and Management of Pruritus in Cholestatic Liver Disease
Journal of Gastroenterology and Hepatology, 04/03/2012
Imam MH et al. – The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. The authors describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.



