Dietary flavonoid intakes and risk of type 2 diabetes in US men and women

American Journal of Clinical Nutrition, 03/08/2012

Wedick NM et al. – A higher consumption of anthocyanins and anthocyanin–rich fruit was associated with a lower risk of type 2 diabetes.

Methods

  • The authors followed up a total of 70,359 women in the Nurses’ Health Study (NHS; 1984–2008), 89,201 women in the NHS II (1991–2007), and 41,334 men in the Health Professionals Follow–Up Study (1986–2006) who were free of diabetes, cardiovascular disease, and cancer at baseline.

Results

  • During 3,645,585 person–years of follow–up, they documented 12,611 incident cases of type 2 diabetes.
  • Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0.85; 95% CI: 0.80, 0.91; P–trend < 0.001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors.
  • Consumption of anthocyanin–rich foods, particularly blueberries and apples/pears was also associated with a lower risk of type 2 diabetes.
  • No significant associations were found for total flavonoid intake or other flavonoid subclasses.

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