The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis Full Text
American Journal of Clinical Nutrition, 09/06/2011
Evidence Based Medicine
Mesas AE et al. – In hypertensive individuals, caffeine intake produces an acute increase in blood pressure (BP) for >=3 h. Current evidence does not support an association between longer–term coffee consumption and increased BP or between habitual coffee consumption and an increased risk of cardiovascular disease (CVD) in hypertensive subjects.
Methods- Systematic review and meta–analysis of publications identified in a PubMed and EMBASE search up to 30 April 2011 was undertaken
- Data were extracted from controlled trials on the effect of caffeine or coffee intake on BP change and from cohort studies on the association between habitual coffee consumption and CVD.
- In 5 trials, the administration of 200–300 mg caffeine produced a mean increase of 8.1 mm Hg (95% CI: 5.7, 10.6 mm Hg) in systolic BP and of 5.7 mm Hg (95% CI: 4.1, 7.4 mm Hg) in diastolic BP.
- The increase in BP was observed in the first hour after caffeine intake and lasted >=3 h
- In 3 studies of the longer–term effect (2 wk) of coffee, no increase in BP was observed after coffee was compared with a caffeine–free diet or was compared with decaffeinated coffee
- 7 cohort studies found no evidence of an association between habitual coffee consumption and a higher risk of CVD.
