A meta-analysis of coffee consumption and pancreatic cancer Full Text
Annals of Oncology, 07/12/2011
Evidence Based Medicine
Turati F et al.– The meta–analysis provides quantitative evidence that coffee consumption is not appreciably related to pancreatic cancer risk, even at high intakes.
Methods- The authors conducted a systematic bibliography search updated March 2011 to identify observational studies providing quantitative estimates for pancreatic cancer risk in relation to coffee consumption.
- They used a meta-analytic approach to estimate overall relative risk (RR) and 95% confidence interval (CI) for the highest versus the lowest coffee consumption categories, using random-effects models.
- Based on 37 case–control and 17 cohort studies (10 594 cases), the pooled RR for the highest versus lowest intake was 1.13 (95% CI 0.99–1.29).
- Considering only the smoking-adjusting studies, the pooled RRs were 1.10 (95% CI 0.92–1.31) for the 22 case–control, 1.04 (95% CI 0.80–1.36) for the 15 cohort, and 1.08 (95% CI 0.94–1.25) for all studies.
- The pooled RR for the increment of one cup of coffee per day was 1.03 (95% CI 0.99–1.06) for the 28 smoking-adjusting studies reporting three or more coffee consumption categories.
- No significant heterogeneity was observed across strata of study design, sex, geographic region, and other selected characteristics.
