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How to measure disease activity in axial spondyloarthritis?
Current Opinion in Rheumatology, 04/27/2011
Machado P et al. – The ASDAS is a well balanced index covering the underlying construct of disease activity and designed to avoid redundancy. It is a feasible and valid measurement instrument with a very good performance compared to existing tools. The ASDAS and its cut-off values may help clinicians and researchers to better assess patients with axial SpA, more reliably determine their disease activity status, the effectiveness of treatments and whether they are providing clinically meaningful improvement.
Methods- The Assessment of Spondyloarthritis international Society (ASAS) developed new index for disease activity measurement in axial SpA: the Ankylosing Spondylitis Disease Activity Score (ASDAS)
- Process closely mimicked development of Disease Activity Score in RA
- Cut-offs for disease activity states and response levels have also been developed
- Good performance of ASDAS has been shown in several international datasets, including randomized controlled trials and observational cohorts