The relationship of vitamin D deficiency to statin myopathy
Atherosclerosis, 03/25/2011
Evidence Based Medicine
Clinical Article
Gupta A et al. – The review suggests that some but not all statins increase 25(OH) D levels. It is presently premature to recommend vitamin D supplementation as treatment for statin associated muscle complaints in the absence of low vitamin D levels although such supplementation could be tried in patients with deficient or reduced vitamin D levels.
Methods- Authors identified English language articles relating statins, vitamin D and statin myopathy via a PubMed search through July 2010.
- Articles pertinent to the topic were reviewed in detail.
- 2 cross sectional studies have associated vitamin D deficiency with statin–associated myalgias, and suggested that that increasing vitamin D levels can reverse the myalgia.
