Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21low cells overexpressing Stra13
European Journal of Immunology, 06/15/2012Visentini M et al.
The findings suggest that marginal zone (MZ) B cells activated by hepatitis C virus (HCV) undergo functional exhaustion associated with BCR signaling defects and overexpression of a key antiproliferative gene, and may subsequently become terminally spent CD21lowB cells. Premature exhaustion may serve to prevent the outgrowth of chronically stimulated MZ B cells.
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