Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population
Hypertension Research, 06/08/2012Virtanen JK et al.
These results suggest that higher serum long–chain n–3 PUFA concentration has a modest inverse association with blood pressure in older men and women.
Data were available for 848 men and 909 women from the Kuopio Ischaemic Heart Disease Risk Factor Study, aged 53–73 years.
Authors excluded participants with ischemic heart disease, stroke, diabetes or hypertension treatment, leaving 396 men and 372 women.
Log–transformed values were used to study the associations.
The mean serum concentrations were 1.63% (s.d. 0.91) for EPA, 0.77% (s.d. 0.16) for DPA and 2.73% (s.d. 0.90) for DHA of all serum fatty acids.
Multivariate–adjusted serum EPA+DPA+DHA was associated with lower systolic blood pressure (β=–4.50, 95% confidence interval (CI) –8.02––0.99) and pulse pressure (β=–4.41, 95% CI –6.95––1.87), but not with diastolic blood pressure (β=–0.45, 95% CI –2.31–1.52).
The associations were similar with EPA, DPA and DHA evaluated individually.
The mean hair mercury concentration was 1.42μgg–1 (s.d. 1.54).
Hair mercury was not associated with blood pressure and it did not modify the association between PUFA and blood pressure.
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