Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population

Hypertension Research, 06/08/2012

These results suggest that higher serum long–chain n–3 PUFA concentration has a modest inverse association with blood pressure in older men and women.


  • Data were available for 848 men and 909 women from the Kuopio Ischaemic Heart Disease Risk Factor Study, aged 53–73 years.
  • Authors excluded participants with ischemic heart disease, stroke, diabetes or hypertension treatment, leaving 396 men and 372 women.
  • Log–transformed values were used to study the associations.
  • The mean serum concentrations were 1.63% (s.d. 0.91) for EPA, 0.77% (s.d. 0.16) for DPA and 2.73% (s.d. 0.90) for DHA of all serum fatty acids.
  • Multivariate–adjusted serum EPA+DPA+DHA was associated with lower systolic blood pressure (β=–4.50, 95% confidence interval (CI) –8.02––0.99) and pulse pressure (β=–4.41, 95% CI –6.95––1.87), but not with diastolic blood pressure (β=–0.45, 95% CI –2.31–1.52).
  • The associations were similar with EPA, DPA and DHA evaluated individually.


  • The mean hair mercury concentration was 1.42μgg–1 (s.d. 1.54).
  • Hair mercury was not associated with blood pressure and it did not modify the association between PUFA and blood pressure.

Print Article Summary Cat 2 CME Report