Examining the correlation between placental and serum placenta growth factor in preeclampsia

American Journal of Obstetrics and Gynecology, 05/11/2012

Serum and placental placenta growth factor (PlGF) are independently associated with preeclampsia and correlated with each other.


  • These analyses were part of a larger, prospective, case–control study. Cases were women with preeclampsia.
  • Controls were women without preeclampsia who delivered at term.
  • Analyses included non–parametric tests to compare medians, logistic regression to estimate odds, and calculation of correlation coefficients.


  • 24 cases (10 preterm, 14 term) were compared to 14 controls.
  • Median levels of PlGF were significantly lower in cases than controls (pPlGF: 232.6 vs. 363.4 pg/mL, p=0.02; sPlGF: 85.5 vs. 274.4 pg/mL, p<0.001).
  • Serum and placental PlGF were correlated (overall: 39%, p=0.006; cases with preterm preeclampsia and growth restriction: 87%, p=0.02).

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