Association between bone mineral density and C-reactive protein in a large population-based sample
Arthritis & Rheumatism, 04/06/2012
de Pablo P et al. – Among men and women in a large representative population–based sample, C–reactive protein (CRP) was inversely and independently associated with total bone mineral density (BMD) in a dose–dependent fashion.
The authors included participants aged 20+ with BMD (total and subregions) measured by dual–energy x–ray absorptiometry (DXA) scans and complete information on covariates from National Health and Nutrition Examination Survey (NHANES) now.
The association between CRP and BMD was evaluated using multivariable linear regression models, adjusting for potential confounders and further adjustment for comorbid diseases, medications and serum vitamin D levels.
The study sample included 10,475 participants, among which there were 53% Caucasians, 22% Mexican–American, 18% African–American, and 7% were other races.
Men had higher BMD and lower CRP concentrations than women.
BMD (total, subtotal, extremities, ribs, and trunk subregions) was inversely associated with CRP quintiles both in men and women in a dose–dependent fashion (total BMD p for trend: <0.0001 for men; 0.0005 for women).
The associations were independent of medications, comorbidities and other potential confounders.
The results remained largely unchanged with further adjustment for serum vitamin D levels.
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