Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease

Pediatric Cardiology, 03/30/2012

Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the Hand1 sympathetic neuron–specific cis–regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed.

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