Intima Media Thickness Variability (IMTV) and its association with cerebrovascular events: A novel marker of carotid atherosclerosis
Cardiovascular Diagnosis and Therapy, 02/29/2012
Saba L et al. – Data of this preliminary study suggest that Intima Media Thickness Variability may represent a powerful method to assess carotid atherosclerotic disease with a significant association to cerebrovascular events.
The study was approved by the local IRB.
Twenty consecutive patients underwent ultrasound analysis of the carotid arteries (mean age 68 years; age range 59–81 years).
The IMT and IMTV of the 40 carotid vessels was assessed.
Bland–Altman statistics were employed to measure the inter–observer variability, and ROC analysis was used to assess the association with cerebrovascular events.
In all cases the ROC area under the curve was higher for IMTV than IMT.
There was a statistical significant association between IMTV and cerebrovascular events (P=0.018), but no relationship between IMT and events.
The results for inter–observer variability showed a systematic error between 0.04 mm and 0.08 mm.
In the Person Rho correlation analysis in no case a statistical association between IMT and symptoms was detected whereas in 2 cases (observer 1 and observer 2), a statistically significant association between IMTV and symptoms was found.
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