Dietary alpha-linolenic acid, linoleic acid, and n–3 long-chain PUFA and risk of ischemic heart disease
American Journal of Clinical Nutrition, 08/29/2011Vedtofte MS et al.
This study suggests that there is no association between alpha–linolenic acid (ALA) intake and risk of ischemic heart disease (IHD), but a high intake of n–3 (omega–3) long–chain (LC)–PUFA had a significant cardioprotective effect in women.
This was a prospective cohort study of 3277 healthy Danish women and men free of known IHD.
471 cases of IHD were observed during a median follow–up period of 23.3 y.
Higher intake of ALA was not significantly associated with decreased risk of IHD among women or men.
Although the HR of IHD was stepwise decreased with increasing ALA intake in men [0.84 (95% CI: 0.62, 1.14) in the medium compared with the lowest tertile (reference) and 0.83 (95% CI: 0.56, 1.24) in the highest compared with the lowest tertile], this change was far from significant (P–trend: 0.39).
No evidence of effect modification by n-3 LC–PUFA or LA was observed.
High n–3 LC–PUFA intake, in comparison with low intake, was inversely associated with risk of IHD; this trend was significant in women (P = 0.04; HR: 0.62; 95% CI: 0.40, 0.97) but not in men (P = 0.15; HR: 0.74; 95% CI: 0.51, 1.06).
No associations were observed between intake of LA and risk of IHD.
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