Subclinical Atherosclerosis and Metabolic Risk: Role of Body Mass Index and Waist Circumference
Metabolic Syndrome and Related Disorders, 03/08/2011
Camhi SM et al. - Adults with elevated metabolic risk have greater intima-media thickness (IMT) than those with normal risk in normal-weight, overweight, low waist circumference (WC), and high WC, but not significant for overweight or moderate WC categories.
Adults from the Bogalusa Heart Study were considered.
They were 24-43 years of age (n=991)
They were classified as normal weight, overweight, or obese and into WC categories (men, low <94cm, moderate 94-101.9 cm, high >=102 cm; women, low <80 cm, moderate 80-87.9 cm, high >=88 cm).
Elevated metabolic risk was defined by cardiovascular risk factor clustering (>=2 abnormal risk factors or insulin resistance (upper quartile of homeostasis model of insulin resistance).
Carotid ultrasound measurements were obtained and mean IMT was calculated.
General linear models compared IMT between elevated versus normal metabolic risk groups, adjusting for sex, age, race/ethnicity, and either BMI or WC category.
41% had elevated metabolic risk (42% male, 28% African American, and 38% obese).
IMT (mm) was greater in adults with elevated metabolic risk (0.83 ± 0.007) versus normal risk (0.80 ± 0.006) whether adjusted by BMI or WC (both P < 0.0005).
IMT was greater in adults with elevated compared to normal metabolic risk within normal-weight (0.84 ± 0.016 vs. 0.79 ± 0.008; P = 0.002), and obese adults (0.86 ± 0.009 vs. 0.80 ± 0.01; P = 0.03), but not significantly different between risk groups in overweight adults.
Similar results were found when stratified by WC category.
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