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1 Effects of medical therapy or surgery on prostatic and bladder resistive indices in patients with benign prostatic hyperplasia Urologia Internationalis, August 19, 2014    Clinical Article

2 Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cells Endocrine-Related Cancer, August 19, 2014    Clinical Article

3 Association of androgen deprivation therapy with excess cardiac-specific mortality in men with prostate cancer BJU International, August 19, 2014    Clinical Article

4 Radiation-induced secondary malignancy in prostate cancer: A systematic review and meta-analysis Urologia Internationalis, August 19, 2014    Evidence Based Medicine    Review Article

5 Stromal nodules in benign prostatic hyperplasia: Morphologic and immunohistochemical characteristics The Prostate, August 19, 2014    Clinical Article

6 Depression, anxiety and self-care behaviours of young adults with Type 2 diabetes: results from the international Diabetes Management and Impact for Long-term Empowerment and Success (MILES) Study Diabetic Medicine, August 19, 2014    Clinical Article

7 The effect of desvenlafaxine 50 mg/day on a subpopulation of anxious/depressed patients: a pooled analysis of seven randomized, placebo-controlled studies Human Psychopharmacology: Clinical and Experimental, August 19, 2014    Clinical Article

8 Correlates of alcohol abstinence and at-risk alcohol consumption in older adults with depression: the NESDO Study The American Journal of Geriatric Psychiatry, August 19, 2014    Clinical Article

9 The association between erectile dysfunction, depressive symptoms and testosterone levels among middle-aged men Scandinavian Journal of Public Health, August 19, 2014    Clinical Article

10 The effect of prenatal Hatha yoga on affect, cortisol and depressive symptoms Complementary Therapies in Clinical Practice , August 19, 2014    Clinical Article

11 Phase-1 study of abiraterone acetate in chemotherapy-naive Japanese patients with castration-resistant prostate cancer Cancer Science, August 19, 2014    Clinical Article

12 A relationship between rem sleep measures and the duration of posttraumatic stress disorder in a young adult urban minority population SLEEP, August 19, 2014    Clinical Article

13 Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease Respirology, August 19, 2014    Clinical Article

14 Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in holocaust survivor offspring American Journal of Psychiatry, August 19, 2014    Evidence Based Medicine    Clinical Article

15 Association of poor subjective sleep quality with risk for death by suicide during a 10-year period: a longitudinal, population-based study of late life JAMA Psychiatry, August 19, 2014    Evidence Based Medicine    Clinical Article

16 Sustained and "sleeper" effects of group metacognitive training for schizophrenia: a randomized clinical trial JAMA Psychiatry, August 19, 2014    Evidence Based Medicine    Clinical Article

17 Acute changes in mood induced by subthalamic deep brain stimulation in Parkinson's disease are modulated by psychiatric diagnosis Brain Stimulation, August 19, 2014    Clinical Article

18 Barriers, benefits, and strategies for physical activity in patients with schizophrenia Physical Therapy, August 19, 2014    Clinical Article

19 Reliability, validity and treatment sensitivity of the Schizophrenia Cognition Rating Scale European Neuropsychopharmacology, August 19, 2014    Clinical Article

20 Effects of live sax music on various physiological parameters, pain level, and mood level in cancer patients: a randomized controlled trial Holistic Nursing Practice, August 19, 2014    Clinical Article

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Highlights in Family Medicine

Belimumab safe and effective in childhood-onset SLE

As reported in Arthritis and Rheumatology, belimumab (a human monoclonal antibody targeting soluble B-lymphocyte stimulator) is effective and well-tolerated in children with SLE (n=7). The mean follow-up was 9.3 months. The SLEDAI decreased from 6.4 to 4 and 57% of recipients were able to taper steroids. Clinical response was evident by 3 months.

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

Tobacco and alcohol use significantly increase risk for ESCC

Based on a meta-analysis (n=5 studies) reported in the American Journal of Gastroenterology, the combined use of tobacco and alcohol increased the risk for esophageal squamous cell carcinoma (OR=3.28) compared with non-users; users of tobacco or alcohol alone had a 20%-30% increased risk of esophageal squamous cell carcinoma compared to non-users.

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