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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Clinical activity of enzalutamide versus docetaxel in men with castration-resistant prostate cancer progressing after abiraterone The Prostate, July 25, 2014    Clinical Article

2 Evidence for molecular differences in prostate cancer between African American and Caucasian men Clinical Cancer Research, July 25, 2014    Clinical Article

3 Population-based analysis of treatment modalities and survival for clinically localized small-cell carcinoma of the prostate Prostate Cancer & Prostatic Diseases, July 25, 2014    Clinical Article

4 Upper limit of cancer extent on biopsy defining very low risk prostate cancer BJU International, July 25, 2014    Clinical Article

5 Development of clinical models for predicting erectile function after localized prostate cancer treatment International Journal of Urology, July 25, 2014    Clinical Article

6 A double-blind, placebo-controlled study of edivoxetine as an adjunctive treatment for patients with major depressive disorder who are partial responders to selective serotonin reuptake inhibitor treatment Journal of Affective Disorders, July 25, 2014    Clinical Article

7 Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder Journal of Psychiatric Research, July 25, 2014    Clinical Article

8 Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymic/depressive states of bipolar disorder Journal of Affective Disorders, July 25, 2014    Clinical Article

9 Application of the gradient Boosted method in randomised clinical trials: Participant variables that contribute to depression treatment efficacy of duloxetine, SSRIs or placebo Journal of Affective Disorders, July 25, 2014    Clinical Article

10 Job loss, wealth and depression during the Great Recession in the USA and Europe International Journal of Epidemiology, July 25, 2014    Clinical Article

11 Postpartum depressive symptoms across time and place: Structural invariance of the Self-Reporting Questionnaire among women from the International, multi-site MAL-ED study Journal of Affective Disorders, July 25, 2014    Clinical Article

12 The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state? Journal of Affective Disorders, July 25, 2014    Clinical Article

13 Major depression in China-to-US immigrants and US-born Chinese Americans: Testing a hypothesis from culture-gene co-evolutionary theory of mental disorders Journal of Affective Disorders, July 25, 2014    Clinical Article

14 Cost effectiveness of telecare management for pain and depression in patients with cancer: Results from a randomized trial General Hospital Psychiatry, July 25, 2014    Clinical Article

15 Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: A potential new tool for diagnosis Journal of Affective Disorders, July 25, 2014    Clinical Article

16 The effect of cognitive functioning on treatment attendance and adherence in comorbid bipolar disorder and cocaine dependence Journal of Substance Abuse Treatment, July 25, 2014    Clinical Article

17 Temperamental differences between bipolar disorder, borderline personality disorder, and attention deficit/hyperactivity disorder: Some implications for their diagnostic validity Journal of Affective Disorders, July 25, 2014    Clinical Article

18 A therapeutic workplace for the long-term treatment of drug addiction and unemployment: Eight-year outcomes of a social business intervention Journal of Substance Abuse Treatment, July 25, 2014    Clinical Article

19 Pain perception in female adolescents with borderline personality disorder European Child and Adolescent Psychiatry, July 25, 2014    Clinical Article

20 Psychiatric disorders and function in adolescents with d-transposition of the great arteries The Journal of Pediatrics, July 25, 2014    Clinical Article

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Highlights in Family Medicine

Visceral adipose tissue predicts subclinical carotid atherosclerosis

As reported in Ultrasound in Medicine and Biology, ultrasound measurement of visceral adipose tissue, unlike the waist circumference, is associated with ultrasound-measured carotid intima-media thickness and an independent predictor of carotid plaques.

Green tea reduces BP and improves lipid profile

As reported in Nutrition, Metabolism, and Cardiovascular Diseases, a meta-analysis involved 20 RCTs and 1536 participants showed that consumption of green tea (Camellia sinensis) is associated with a reduction in systolic blood pressure (-1.94 mmHg) and improved lipid profile (TC, -0.13 mmol/l; LDL-C, -0.19 mmol/l). Additional studies quantifying the association are needed.

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

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