The Latest Journal Articles in Family Medicine

1Efficacy of a vaporization-resection of the prostate median lobe enlargement and vaporization of the prostate lateral lobe for benign prostatic hyperplasia using a 120-W GreenLight high-performance system laser: The effect on storage symptomsLasers in Medical Science, April 24, 2015  Clinical Article
2Comparative effectiveness of mitoxantrone plus prednisone versus prednisone alone in metastatic castrate-resistant prostate cancer after docetaxel failureThe Oncologist, April 24, 2015  Full Text  Clinical Article
3The relationship between symptom relief and functional improvement during acute fluoxetine treatment for patients with major depressive disorderJournal of Affective Disorders, April 24, 2015  Clinical Article
4Rate of Gleason 7 or higher prostate cancer on repeat biopsy after a diagnosis of atypical small acinar proliferationProstate Cancer & Prostatic Diseases, April 24, 2015  Clinical Article
5Development of a preliminary nomogram to predict progression of bone scan for castration-resistant prostate cancerOncoTargets and Therapy, April 24, 2015  Full Text  Clinical Article
6Omega-3 fatty acids and cognitive declineAmerican Journal of Lifestyle Medicine, April 24, 2015  Clinical Article
7Risk factors for biochemical recurrence after robotic assisted radical prostatectomy: A single surgeon experienceBMC Urology, April 24, 2015  Full Text  Clinical Article
8Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsyInternational Braz J Urol, April 24, 2015  Full Text  Clinical Article
9Comparing PROMIS to Legacy depression measures in a community sample of older adults with varying levels of cognitive functioningThe American Journal of Geriatric Psychiatry, April 24, 2015  Clinical Article
10Sexual dysfunction during treatment of major depressive disorder with vilazodone, citalopram, or placebo: Results from a phase IV clinical trialInternational Clinical Psychopharmacology, April 24, 2015  Clinical Article
1Viral proteins may regulate human embryonic developmentStanford School of Medicine News, April 24, 2015
2Cognitive problems are common after cardiac arrestLund University News, April 24, 2015
3Emotional problems in schoolgirls rose dramatically over past 5 yearsUniversity College London New, April 24, 2015
4Statins show promise as a prevention tool for adults 75 and older, OSU study showsOregon State University News, April 24, 2015
5Delayed diagnosis of coeliac disease may put lives at risk: Is screening the solution?United European Gastroenterology News, April 24, 2015
6New research shows how to tackle obesityThe University of Sheffield News, April 24, 2015
7Online program to combat OCDQueensland Brain Insitute News, April 24, 2015
8Kids with ADHD must squirm to learn, UCF study saysUniversity of Central Florida Health News, April 24, 2015
9More detailed findings confirm that coffee protects against breast cancer recurrenceLund University News, April 24, 2015
10Mindfulness-based therapy may offer alternative to antidepressantsUniversity of Oxford News, April 24, 2015

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Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

Combination tiotropium + formoterol superior to tiotropium alone in COPD patients

As reported in Pulmonary Pharmacology & Therapeutics, combination tiotropium (18 mcg) + formoterol (12 mcg) was superior to tiotropium alone in COPD (n=44) patients inadequately controlled with bronchodilator monotherapy. Combination therapy resulted in an increased bronchodilator response (FEV1 and FVC) and a maximum change in FEV1 and FVC over 24 h.

Belimumab safe and effective in childhood-onset SLE

As reported in Arthritis and Rheumatology, belimumab (a human monoclonal antibody targeting soluble B-lymphocyte stimulator) is effective and well-tolerated in children with SLE (n=7). The mean follow-up was 9.3 months. The SLEDAI decreased from 6.4 to 4 and 57% of recipients were able to taper steroids. Clinical response was evident by 3 months.

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Clinical Pearls

Clinical Pearl from Smartest DocEine Hyponatriämie ist bei stationären Herzinsuffizienz-Patienten mit einer sehr hohen Krankenhausmortalität assoziiert.

Clinical Pearl from Smartest DocBei Linagliptin ist keine Dosisanpassung bei eingeschränkter Nierenfunktion erforderlich.

Clinical Pearl from Smartest DocGeriatrische Patienten sollten unter Behandlung mit atypischen Neuroleptika reguläre Screenings auf Diabetes erhalten.

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