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1 Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial The Lancet Oncology, July 29, 2014    Clinical Article

2 Comparison of fracture risk assessment tool score to bone mineral density for estimating fracture risk in patients with advanced prostate cancer on androgen deprivation therapy Urology, July 29, 2014    Clinical Article

3 Disease-specific death and metastasis do not occur in patients with Gleason score ≤ 6 on radical prostatectomy BJU International, July 29, 2014    Clinical Article

4 Diabetes mellitus and the risk of mortality among patients with prostate cancer: a meta-analysis of 11 cohort studies Diabetes/Metabolism Research and Reviews, July 29, 2014    Evidence Based Medicine    Clinical Article

5 Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review Clinical Gastroenterology and Hepatology , July 29, 2014    Evidence Based Medicine    Review Article

6 The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review Current Drug Targets, July 29, 2014    Review Article

7 Physical, lifestyle, psychological and social determinants of pain intensity, pain disability and the number of pain locations in depressed older adults Pain, July 29, 2014    Clinical Article

8 The use of a single daily dose of tadalafil to treat signs and symptoms of benign prostatic hyperplasia and erectile dysfunction Full Text Research and Reports in Urology, July 29, 2014    Clinical Article

9 Lovastatin for the adjunctive treatment of schizophrenia: A preliminary randomized double-blind placebo-controlled trial Psychiatry Research, July 29, 2014    Clinical Article

10 Urticaria in adolescence increases the risk of developing new-onset depression: A database study Full Text Journal of Acute Medicine, July 29, 2014    Clinical Article

11 Randomized controlled trial of interpersonal psychotherapy versus enhanced treatment as usual for women with co-occurring depression and pelvic pain Journal of Psychosomatic Research, July 29, 2014    Evidence Based Medicine

12 Examining posttraumatic stress disorder's latent structure between treatment-seeking and non-treatment-seeking Filipinos Asian Journal of Psychiatry, July 29, 2014    Clinical Article

13 Depressive symptoms predict incident dementia during short- but not long-term follow-up period Alzheimer's & Dementia, July 29, 2014    Clinical Article

14 Are psychotherapeutic interventions effective in late-life depression?: A systematic review Psychiatrische Praxis, July 29, 2014    Evidence Based Medicine

15 Arginine and asymmetric dimethylarginine in pregnant women with major depression Psychosomatic Medicine, July 29, 2014    Clinical Article

16 The relationship between self-image and social anxiety in adolescence Child and Adolescent Mental Health, July 29, 2014    Clinical Article

17 Telomere shortening and immune activity in war veterans with posttraumatic stress disorder Progress in Neuro-Psychopharmacology and Biological Psychiatry, July 29, 2014    Clinical Article

18 Validation of the Communication Skills Questionnaire (CSQ) in people with schizophrenia Psychiatry Research, July 29, 2014    Clinical Article

19 Metacognition in psychosis: Comparison of schizophrenia with bipolar disorder Psychiatry Research, July 29, 2014    Clinical Article

20 Parental changes after involvement in their anxious child's cognitive behavior therapy Journal of Anxiety Disorders, July 29, 2014    Clinical Article

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Highlights in Family Medicine

Predictors of poor coronary collateral circulation in stable CAD

As reported in Angiology, the fasting blood glucose and serum uric acid levels and the white blood cell count were higher in patients with stable CAD (n=480) and associated with poor coronary collateral circulation.

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

Green tea reduces BP and improves lipid profile

As reported in Nutrition, Metabolism, and Cardiovascular Diseases, a meta-analysis involved 20 RCTs and 1536 participants showed that consumption of green tea (Camellia sinensis) is associated with a reduction in systolic blood pressure (-1.94 mmHg) and improved lipid profile (TC, -0.13 mmol/l; LDL-C, -0.19 mmol/l). Additional studies quantifying the association are needed.

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