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Tiemstra J et al. – In this predominantly young, adult population with acute pharyngitis, non–GAS infection was as common as GAS infection and was associated with the same clinical features typically associated with GAS. Although the benefits of treating non–GAS pharyngitis in terms of either symptomatic relief or prevention of sequelae are unproven, clinicians may want to consider treating patients with proven or presumptive non–GAS pharyngitis who fail to respond to symptomatic therapy or who are at increased risk for sequelae of group B or group C streptococcal infections, such as those patients who are or have close contact with pregnant women, neonates, and elderly or immunocompromised persons. Further study is needed to determine whether patients with non–GAS pharyngitis benefit from targeted antibiotic treatment.


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