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See Latest ArticlesNuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
Annals of Oncology, 10/30/09
Chung CH et al. – Further understanding of treatment resistance and interactions between bortezomib and docetaxel may provide novel approaches in managing HNSCC.
Methods- Patients with recurrent and/or metastatic HNSCC enrolled on phase II bortezomib/docetaxel trial (bortezomib 1.6 mg/m2 and docetaxel 40 mg/m2 on days 1 and 8 of a 21-day cycle)
- Response assessed using RECIST
- Tissue specimens evaluated for presence of HPV and expression of NF-B-associated genes
- 21 of 25 enrolled patients were assessable for response; one partial response , 10 stable disease and 10 progressive disease
- Patients with PR/SD had significantly longer survival compared with patients with PD and regimen was well tolerated
- Only 1 of 20 tumors was positive for HPV
- Patients with PD had higher expression of NF-B and epidermal growth factor receptor-associated genes in their tumors by gene expression analysis
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Laryngeal steroid injection
Current Opinion in Otolaryngology and Head & Neck Surgery, 11/20/09
Ceftriaxone for Refractory Acute Otitis Media: Impact of a Clinical Practice Guideline
Pediatric Emergency Care, 11/17/09
Propranolol treatment for infantile hemangiomas
Current Opinion in Otolaryngology and Head & Neck Surgery, 11/13/09
Today in Head and Neck...keeping you current
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Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
Oncology (Karger), 11/20/09
Central Neck Dissection for Papillary Thyroid Cancer
Archives of Otolaryngology, 11/20/09
Pediatric head and neck malignancies
Current Opinion in Otolaryngology and Head & Neck Surgery, 11/20/09
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