ENT Medical News about Glial Cell Line-Derived Neurotrophic Factor

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Effects of Neurotrophic Factors on Growth and Glial Cell Alignment of Cultured Adult Spiral Ganglion Cells
Audiology & Neuro-Otology, 10/23/09

Rask–Andersen H et al. – GDNF had a strong effect on spiral ganglion cell growth almost attaining the level of all three factors in combination. GDNF increased glial cell alignment and nerve bundle formation. Results show the potential of GDNF to maintain and possibly restore auditory nerve integrity.

Exclusive Author Commentary
Prof. Helge Rask-Andersen, 10/26/09

This paper is the result of almost eight years experience of the use of GDNF on spiral ganglion cell growth in culture uring both human and experimental animals in Uppsala, Sweden. We were surprised to see the positive effects of GDNF compared to NT3 and BDNF that also, in combination, have positive effects on growth of the auditory nerve. By using time lapse video recordings we could verify the trophic effects but also nuclear translocation, "ganglionization" and alignement of glia/Schwann cells. We developed a computer basewd technique to reliably assess neurite growth. GDNF may not only have trophic effects but also proliferative but this needs even more substantiation. We believe GDNF may be used in the near future to potentiate neuron protection in combination with inner ear surgery such as cochlear implantation and EAS. surgery.

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