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Pretreatment prognostic factors influencing distant metastasis-free survival in locally advanced squamous cell carcinoma of the head and neck treated with radiation therapy with or without concurrent chemotherapy
American Journal of Clinical Oncology, 10/09/09

Jerimic B et al. – This analysis showed that only stage grouping and concurrent CHT predicted DMFS in patients with locally advanced squamous cell carcinoma of the head and neck treated with RT with and without concurrent low-dose daily CHT. These results may have implication for future studies in this disease.

Methods

2 consecutive prospective randomized trials
289 patients treated with standard fraction (conventionally fractionated [CF]) or hyperfractionated radiation therapy with or without concurrent low-dose daily platinum chemotherapy (CHT)

Results

Kaplan-Meier analysis showed that gender and age did not influence DMFS
T stage , and primary tumor location . N stage , stage grouping , treatment , and concurrent CHT influenced DMFS
Univariate Cox analysis showed treatment lost significance, whereas N staging became marginally insignificant
Multivariate Cox analysis showed that only lower stage grouping and addition of concurrent CHT were independent prognosticator of improved DMFS

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