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Prognostic factors in oropharyngeal cancer - analysis of 627 cases receiving definitive radiotherapy
Acta Oncologica, 09/25/09

Agarwal JP et al. – Oropharyngeal cancers in those without a history of tobacco abuse may be biologically different and more amenable to cure with radiotherapy.

Methods

The records of 627 patients with oropharyngeal cancer treated with radical radiotherapy with conventional techniques were analyzed

Results

History of tobacco abuse was present in 80.5%
Radical radiotherapy alone was the treatment modality for 71.2% and concomitant or neoadjuvant chemotherapy was used in 28.8%
The 3-year local control (LC), loco-regional control (LRC), DFS and OS was 49%, 40.6%, 38.9% and 36.1% respectively
The 3-year DFS rates were 80.3% for stage I, 65.8% for stage II, 46.1% for stage III and 25.2% for stage IV disease
Prior history of tobacco abuse was an independent prognostic factor for both DFS and LRC
Karnofsky Performance Score (KPS) < 80, higher nodal stage, lower total radiotherapy dose (<66 Gy) in those receiving > 60 Gy, and overall treatment time > 50 days were other independent prognostic factors for inferior DFS and LRC
KPS < 80, higher T stage, higher nodal stage, RT dose < 66 Gy and longer overall treatment time (>50 days) were independent prognostic factors for poorer local control

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