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Psoriasin (S100A7), an antimicrobial peptide, is increased in human middle ear cholesteatoma
Acta Oto-Laryngologica , 09/18/09

Kim KH et al. – By real–time PCR, expression levels of psoriasin mRNA in cholesteatoma were significantly higher than in normal external auditory canal skin, and this was confirmed by Western blotting. Immunohistochemical staining revealed that psoriasin protein is mainly expressed in the granular layer and in the upper parts of the spinous layer in cholesteatoma epithelium, but that it is expressed in the superficial layer of normal external auditory canal skin.

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