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Antigen-dependent rescue of nose-associated lymphoid tissue (NALT) development independent of LT[beta]R and CXCR5 signaling
European Journal of Immunology, 09/28/09

Krege J et al. – This allows for the formation of high endothelial venules and thereby the recruitment of lymphocytes into NALT. Alternatively, high endothelial venule formation and lymphocyte recruitment can be induced in the NALT anlage by environmental signals, which are independent of LT–betaR and chemokine receptor CXCR5 signaling but in part rely on CD40 ligand. Thus, our study identifies a novel mechanism that facilitates the rescue of NALT development at late stages in adult life independent of the canonical LTbetaR–CXCR5 signaling axis.

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