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Limitations of PET/CT in determining need for neck dissection after primary chemoradiation for advanced head and neck squamous cell carcinoma
Journal for Oto-Rhino-Laryngology, 09/16/09

Lyford-Pike S et al. – PET/CT is neither highly sensitive nor highly specific for identifying residual nodal metastases after CRT for advanced-stage HNSCC.

Methods

Retrospective study
38 patients received primary CRT for HNSCC with N2 or greater disease, PET/CT after treatment and neck dissection
PET/CT results were correlated with pathology results from neck dissection specimens for each respective side

Results

46 neck regions were analyzed
9 were determined to have either PET/CT result reports (n = 5) or pathology reports (n = 4) that were indeterminate
PET/CT demonstrated a sensitivity and specificity of 57.1% and 73.9%, respectively, an accuracy of 67.5%, a positive predictive value of 57.1% and a negative predictive value of 73.9% when compared to the final pathology

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Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastases
Journal of Cutaneous Pathology, 11/18/09 Relevance Score: 91%

Invasive papillary carcinoma of the male breast: Report of a rare case and review of the literature
Journal of Cancer Research and Therapeutics, 10/28/09 Relevance Score: 91%

Spread of Squamous Cell Carcinoma From the Thumb to the Small Finger via the Flexor Tendon Sheaths
The Journal of Hand Surgery, 11/16/09 Relevance Score: 90%

Local Biosynthesis of Estrogen in Human Endometrial Carcinoma through Tumor-Stromal Cell Interactions
Clinical Cancer Research, 10/06/09 Relevance Score: 90%

H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1
Human Pathology, 11/12/09 Relevance Score: 89%