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See Latest ArticlesMucin gene polymorphisms in otitis media patients
The Laryngoscope, 08/31/09
Ubell ML et al. – In otitis media, OME patients are more likely than controls or RecOM to carry the longer MUC5AC–b allele. MUC5AC is a primary innate defense mechanism for ME epithelium, and alterations in protein structure have the potential to affect that defense and predispose patients to disease. This study demonstrates that the properties of post–transcriptionally modified MUC5AC deserve further study, and specific pathogen–host interactions studies should explore the impact of this polymorphism.
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