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Prospective Trial Incorporating Pre-/Mid-Treatment [18F]-Misonidazole Positron Emission Tomography for Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy
International Journal of Radiation Oncology*Biology*Physics, 08/31/09
Lee N et al. – Excellent locoregional control was observed in this series of head–and–neck cancer patients treated with concurrent platinum–based chemotherapy and intensity–modulated radiotherapy despite evidence of detectable hypoxia on the pretreatment 18F–FMISO PET/computed tomography scans of 18 of 20 patients. In this prospective study, neither the presence nor the absence of hypoxia, as defined by positive 18F–FMISO findings on the mid–treatment PET scan, correlated with patient outcome.
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