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99mTc-sestamibi scanning in thyroid nodules with nondiagnostic cytology
Head & Neck, 09/02/09

Giovanella L et al. – A negative MIBI scan in a cold nodule accurately excludes malignancy when US–FNAC is reported as nondiagnostic. This avoids the need for more invasive diagnostic procedures (ie, surgery) and positively influences the cost–effectiveness profile. A MIBI scan may be performed by acquiring images 30 minutes after tracer administration alone. Histology is still necessary to distinguish benign from malignant disease in a MIBI–positive nodule but unnecessary surgery could have been reduced from 71 to 8 cases in the series.

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