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Age as a determinant of outcomes for patients with oral cancer
Oral Oncology , 08/06/09

Goldenberg D et al. - In a study to determine whether survival outcomes of younger pts with oral cavity squamous cell cancer (OSCC) differs from older pts in the US, these results confirm recent results using population-based data that suggest better overall survival in younger pts.

Methods

A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry.
Cases (n=19681) of OSCC diagnosed from 1973 to 1999 were studied and age cutoffs were used at 40, 45, 50, and 55 yrs.
Control groups of older pts were retrospectively matched on gender, race, cancer subsite, and stage of disease.
Survival was estimated using the Kaplan–Meier method.
A propensity score matching produced groups with similar distributions of pt and disease characteristics.

Results

Between these matched groups, younger pts had a significantly better 5-yr survival (age 40: 63.4% vs 80.6%; age 45: 59.0% vs 72.8%; age 50: 55.5% vs 67.2%; age 55: 54.0% vs 64.3%).

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