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See Latest ArticlesN1-guanyl-1,7,-diamineoheptane, an inhibitor of deoxyhypusine synthase, suppresses differentiation and induces apoptosis via mitochondrial and AMPK pathways in immortalized and malignant human oral keratinocytes
Journal of Oral Pathology and Medicine, 07/28/09
Lee SK et al. – The results demonstrate that GC7 blocks immortalized and malignant keratinocyte cell proliferation and differentiation by inducing apoptosis through the mitochondrial and AMPK pathways. On the basis of these observations, the authors propose that a strategy combining GC7 and AMPK inhibition could be developed into a novel chemotherapeutic modality in oral cancer.
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Surgical Outcome in Patients with Oral Verrucous Carcinoma: Long-Term Follow-Up in an Endemic Betel Quid Chewing Area
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