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See Latest ArticlesComparative proteomical and metalloproteomical analyses of human plasma from patients with laryngeal cancer
Cancer Immunology, Immunotherapy, 07/28/09
Gomes CPC et al. – In a study to evaluate the plasmas of pts with laryngeal cancer, the study reinforces the importance of the immune response as target in the understanding and treatment of laryngeal cancer and the possibility that chromium is important in the carcinogenic progress.
Methods- Plasmas of pts with laryngeal cancer and of healthy smokers were evaluated by 2D gel electrophoresis and mass spectrometry.
- Proteins were detected on every gel around pH 4.0–10.0 from molecular mass of 10–60 kDa.
- Few differences were found among cancer and control pts.
- 3 spots gathered between pI 7.3 and 7.6 with different molecular masses appeared exclusively in cancer profiles.
- From 10 spots identified, 6 correspond to immune system components, including the 3 differential ones.
- The latter were observed only in cancer pts.
- Presence of several trace elements in the identified proteins was determined by inductively coupled plasma mass spectrometry, where chromium was increased in all proteins analyzed from pts with cancer.
Octavio Luiz Franco, 07/28/09
| Data reported in this article associate the use of proteomics and metallo-proteomics in order to understand the immune response modifications in human plasma of patients with laryngheal cancer |
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