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Khalid SK et al. – Hereditary hemorrhagic telangiectasia patients with high–output cardiac failure have significantly greater nose bleeding as compared with patients without high–output cardiac failure. In addition, nose bleeding worsens around the time of development of high–output cardiac failure. Early recognition of the relationship between severe nose bleeding and high–output cardiac failure can lead to earlier diagnosis and provide an opportunity for earlier institution of therapy for high–output cardiac failure.

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