ENT Medical News about cisplatin, cancer of the nasal cavity and paranasal sinuses

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Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses
Cancer, 07/31/09

Homma A et al. - In a study to evaluate the efficacy of superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT) for previously untreated pts with advanced cancer of the nasal cavity and paranasal sinuses, it was found that, although a single institution experience, results suggest that RADPLAT can cure the majority of pts with advanced cancer of the nasal cavity and paranasal sinuses, as well as preserve organs.

Methods

47 pts were given superselective intra-arterial infusions of cisplatin (100-120 mg/m2/wk) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional external-beam radiotherapy (65-70 grays).

Results

There were 7 pts (14.9%) diagnosed with T3, 22 (46.8%) with T4a, and 18 (38.3%) with T4b disease.
During the median follow-up period of 4.6 yrs, 5-yr local progression-free survival rate was 78.4% for all pts (n=47), 69.0% for pts with T4b disease (n=18), and 83.2% for pts with
5-yr overall survival rate was 69.3% for all pts, 61.1% for pts with T4b disease, and 71.1% for pts with
RADPLAT was feasible in 45 pts (95.7%).
No pt died as a result of treatment toxicity or had a cerebrovascular accident.
Osteonecrosis (n=7), brain necrosis (n=2), and ocular/visual problems (n=16) were observed as late adverse reactions.

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