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TGF-beta signaling and collagen deposition in chronic rhinosinusitis
Journal of Allergy and Clinical Immunology, 07/22/09
Bruaene NV et al. – A high TGF–beta 1 protein expression, increased TGF–beta RI expression, and a high number of pSmad 2–positive cells all indicate an enhanced TGF–beta signaling in CRSsNP, whereas a low TGF–beta 1 protein concentration, a decreased expression of TGF–beta RII, and a low number of pSmad 2–positive cells in CRSwNP indicate a low level of TGF–beta signaling in CRSwNP.
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