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Radiation therapy for minor salivary gland carcinoma
The Laryngoscope, 06/10/09

Cianchetti M et al. - In a study to analyze the outcomes of pts treated for minor salivary gland carcinoma with radiotherapy (RT), either alone or combined with surgery, it was found that most pts with minor salivary gland carcinoma were cured with RT alone or combined with surgery. Treatment group, T stage, and overall stage significantly influenced the probability of cure. Pts treated with combined surgery and RT had a better prognosis, perhaps due in part to selection bias.

Methods

140 pts were treated with curative intent for previously untreated minor salivary gland carcinomas (RT alone, 64 pts; combined RT and surgery, 76 pts).
Median follow-up for all pts was 5.5 yrs.

Results

10-yr local control rate was 66%, and multivariate analysis revealed that treatment group and T stage significantly influenced this endpoint.
Pts treated with RT alone had a lower local control rate than pts treated with RT and surgery.
10-yr local-regional control rate was 61%, and multivariate analysis revealed that treatment group, overall stage, and N stage significantly influenced this endpoint.
10-yr distant metastasis-free survival rate was 67%, and multivariate analysis revealed that overall stage significantly influenced this endpoint.
10-yr cause-specific survival rate was 56%, and multivariate analysis revealed that overall stage significantly influenced this endpoint.
10-yr overall survival rate was 45%, and multivariate analysis revealed that overall stage, N stage, and nerve invasion significantly influenced this endpoint.

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