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See Latest ArticlesProton therapy for maxillary sinus carcinoma
American Journal of Clinical Oncology, 06/08/09
Chera BS et al. – Study shows that both three-dimensional conformal proton therapy (3DCPT) and intensity-modulated radiotherapy (IMRT) sufficiently covered the target volume(s) for a paranasal sinus malignancy. Although 3DCPT reduced the mean and integral dose to all of the normal tissues, both 3DCPT and IMRT irradiated the ipsilateral optic structures beyond acceptable tolerance doses.
Methods- A comparison of the dose-volume data of 3DCPT vs IMRT for a paranasal sinus malignancy
- 3DCPT and IMRT plans were created for a T4N0 maxillary sinus carcinoma
- Target volume dose distributions were comparable for 3DCPT and IMRT
- Mean and integral doses for all normal tissues were lower for 3DCPT
- Maximum doses for both plans to the ipsilateral optic nerve/retina/lens, temporal lobe, pituitary, and brain exceeded tolerance doses
- The contralateral parotid, lacrimal gland, and lens were avoided with 3DCPT
- Neither 3DCPT nor IMRT exceeded the max tolerated dose for the brainstem, optic chiasm, contralateral temporal lobe, parotid, or lacrimal gland
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