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Proton therapy for maxillary sinus carcinoma
American Journal of Clinical Oncology, 06/08/09

Chera BS et al. – Study shows that both three-dimensional conformal proton therapy (3DCPT) and intensity-modulated radiotherapy (IMRT) sufficiently covered the target volume(s) for a paranasal sinus malignancy. Although 3DCPT reduced the mean and integral dose to all of the normal tissues, both 3DCPT and IMRT irradiated the ipsilateral optic structures beyond acceptable tolerance doses.

• A comparison of the dose-volume data of 3DCPT vs IMRT for a paranasal sinus malignancy
• 3DCPT and IMRT plans were created for a T4N0 maxillary sinus carcinoma

• Target volume dose distributions were comparable for 3DCPT and IMRT
• Mean and integral doses for all normal tissues were lower for 3DCPT
• Maximum doses for both plans to the ipsilateral optic nerve/retina/lens, temporal lobe, pituitary, and brain exceeded tolerance doses
• The contralateral parotid, lacrimal gland, and lens were avoided with 3DCPT
• Neither 3DCPT nor IMRT exceeded the max tolerated dose for the brainstem, optic chiasm, contralateral temporal lobe, parotid, or lacrimal gland

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