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See Latest ArticlesPneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics
Vaccine , 06/03/09
Poolman J et al. - A possible alternative explanation may lie with the atypically abundant expression of capsular polysaccharide which could make serotype 3 strains less susceptible to anti-polysaccharide antibody defence mechanisms in the middle ear. The occurrence of acapsular forms during biofilm growth may also play a role. Clinical impact against otitis media, of vaccines containing pneumococcal serotype 3 components, remains unclear until further investigations have demonstrated the value.
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