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Your Article Summary
Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes
International Journal of Cancer, 05/18/09
Abbasi R et al. - When tested for gene-gene interaction, presence of 3 risk alleles in the XPC-RAD23B complex increased the risk 2.1-fold. SNPs in the other genes did not show a significant association with laryngeal cancer risk. The authors conclude that common genetic variations in NER genes can significantly modify laryngeal cancer risk.
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