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See Latest ArticlesMetastatic cutaneous squamous cell carcinoma to the parotid and cervical lymph nodes: Treatment and outcomes
Current Opinion in Otolaryngology and Head & Neck Surgery, 04/30/09
Bumpous J - The identification of 'high-risk' patients with head and neck cutaneous squamous cell carcinoma (SCC) is imperative to improve patient outcome. Surgical management of the parotid and neck are important aspects of management, and application of radiation in the adjuvant setting improves locoregional disease control.
Methods- A review of the current literature regarding head and neck cutaneous SCC with respect to implications of parotid and cervical metastasis
- A subset of head and neck cutaneous SCCs are aggressive
- Parotid and cervical nodal involvement represents a poor prognosis
- Assessment of nodal and parotid involvement allows the surgeon to identify pts at high risk for recurrence and poor survival
- Overexpression of the epidermal growth factor receptor (EGFR) is present in pts with lymphatic metastasis
- Surgical treatments like sentinel lymph node biopsy, and lymphoscintigraphy-specific lymphadenectomy in clinically negative necks are available
- In addition to established cervical nodal basins of levels I-VI, parotid, buccal, and external jugular basins are relevant in managing these pts
- Application of radiation therapy in an adjuvant setting provides enhanced local regional control in pts with positive parotid and neck nodes
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