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Chronic periodontitis–human papillomavirus synergy in base of tongue cancers
Archives of Otolaryngology, 04/22/09

Tezal M et al. - In a study to assess whether chronic periodontitis history predicts human papillomavirus (HPV) status in pts with base of tongue cancers, chronic periodontitis may be a significant factor in the natural history of HPV infection in pts with base of tongue cancers.

Methods

30 pts newly diagnosed with base of tongue squamous cell carcinoma for whom both tumor samples and periodontal records were available.
Pts younger than 21 yrs, edentulous, immunocompromised, and those with a history of cancer were excluded.
Periodontitis history was assessed on the basis of alveolar bone loss (in millimeters) from panoramic radiographs by 1 examiner who was blinded to cancer status.
HPV-16 and HPV-18 DNA were identified on paraffin-embedded tumor samples by polymerase chain reaction.
Multiple logistic regression was used to estimate odds ratios and 95% confidence intervals.

Results

Prevalence of tumors positive for HPV-16 DNA was 21 of 30 (70%).
None of the samples were positive for HPV-18 DNA.
Compared with participants with HPV-negative tumors, pts with HPV-positive tumors had significantly higher mean alveolar bone loss (3.90 mm vs 2.85 mm).
After adjustment for age at diagnosis, sex, race/ethnicity, alcohol use, smoking status, and number of missing teeth, every millimeter of alveolar bone loss was associated with an approximately 4-fold increased risk of HPV-positive tumor status.
Number of missing teeth was not associated with tumor HPV status.

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