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Clinical predictors of quality of life in patients with initial differentiated thyroid cancers
Archives of Otolaryngology, 04/21/09

Almeida J et al. - In a trial to assess the quality of life (QOL) of pts with differentiated thyroid cancer (DTC) and its potential clinical predictors, it was found that although QOL after treatment can be considered good for most pts, those submitted to radioactive iodine therapy (RIT) at doses higher than 150 mCi are at risk for poor QOL and may need more intensive follow-up and treatment.

Methods

154 pts submitted to thyroidectomy (1997-2006) were evaluated using the University of Washington Quality of Life questionnaire.
Descriptive analysis of the results was done as bivariate and multivariate analyses to compare each independent variable with each of 13 QOL domains.

Results

Pts 45 yrs or younger had better recreation scores than did pnts older than 45 yrs.
38 pts were submitted to neck dissection.
Pts submitted to modified radical neck dissection reported worse chewing and shoulder scores than did pts submitted to selective paratracheal lymph node dissection only and those without neck dissection.
Pts who received >150 mCi of RIT reported significantly worse pain, swallowing, chewing, speech, taste, anxiety, and composite scores.
Comorbidities showed significant effect on recreation, activity, speech, saliva, and composite scores.
In multivariate analysis, RIT is the only variable associated with a worse composite score.

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