ENT Medical News about HPV;subgroup of sinonasal squamous cell carcinomas;favorable outcome

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Appropriate Antibiotic Use for Acute Otitis Media

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Human papillomaviruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome
Cancer, 04/16/09

Alos L et al. - In a study to evaluate the role of human papillomavirus (HPV) in the pathogenesis of squamous cell carcinomas (SCCs) of the sinonasal tract and its clinicopathological implications, it appears that a subgroup of sinonasal SCCs is associated with HPV infection. These tumors have a significantly better prognosis.

Methods

All SCCs of the sinonasal tract diagnosed were retrospectively evaluated (n = 60).
Clinical and pathological data were reviewed.
HPV infection was determined and typed by amplification of HPV DNA by polymerase chain reaction using the SPF-10 primers.
p16INK4a expression was determined by immunohistochemistry.
Overall (OS) and progression-free survival (PFS) for HPV-positive and -negative pts was estimated by Kaplan-Meier analysis and by use of a multivariate Cox proportional hazards model.

Results

HPV DNA was detected in tumor tissue of 12 of 60 (20%) pts.
HPV16 was identified in 11 tumors and HPV35 in 1.
Immunohistochemistry for p16INK4a stained all HPV-positive and no HPV-negative tumors.
No differences were observed in terms of site and histological grade or stage at presentation between HPV-positive and -negative tumors.
HPV-positive pts had a significantly better 5-yr PFS and OS than pts with HPV-negative tumors.
In multivariate analysis, HPV-positive tumors were associated with improved PFS.

<< Previous
Hearing Assistance Technology: Integrating HATs into Clinical...

Next >>
Adherence, compliance key with underinsured