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See Latest ArticlesAudiometric, surgical, and genetic findings in 15 ears of patients with osteogenesis imperfecta
The Laryngoscope, 04/17/09
Swinnen FKR et al. - In general, stapes surgery is successful in resolving the conductive hearing loss in OI patients, even in the long term. Hearing loss in OI is mostly of the mixed type, and the sensorineural component is reported to be progressive. Stapedotomy, by improving the hearing level, may facilitate the rehabilitation with a hearing aid. Because the identified mutation could be located in the COL1A1 gene in all patients, conductive hearing loss in OI caused by stapes fixation is possibly linked to a mutation in this gene.
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