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Ikram M et al. - The onset of allergic fungal sinusitis occurs with the inhalation of fungal spores to which the patient is allergic. In response, the sinonasal mucosa produces a copious amount of secretions (mucin), but the process of mucociliary clearance fails to remove the spore. The fungal spore then germinates in the mucin and continues to provide an antigenic stimulus. Polyps and hyperplastic mucosa form as a result of the inflammatory stimulus.The diagnostic criteria for allergic fungal sinusitis include the presence of nasal polyposis, atopy to fungi, characteristic findings on computed tomography.


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