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Relevance of the hygiene hypothesis to early vs. late onset allergic rhinitis
Clinical and Experimental Allergy, 02/04/09
Matheson MC et al. - Exposures relevant to the hygiene hypothesis were important predictors for the development of early onset but less so for later onset allergic rhinitis. The exact mechanisms by which siblings and infections protect against allergic rhinitis are unclear. The stronger findings for earlier onset allergic rhinitis suggest that family structure and infections have most impact on disease risk in early life.
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