Endocrinology Medical News about Glucose Metabolism

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Peroxisome Proliferator-Activated Receptor-alpha Control of Lipid and Glucose Metabolism in Human White Adipocytes
Endocrinology, 11/06/09

Ribet C et al. – Small interfering RNA–mediated extinction of PPARalpha gene expression in hMADS adipocytes attenuated GW7647 induction of palmitate oxidation. Rosiglitazone had no major impact on glycolysis and beta–oxidation. Altogether these results show that PPARalpha can selectively up–regulate beta–oxidation and decrease glucose utilization in human white adipocytes.

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