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See Latest ArticlesCentral Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation
Endocrinology, 11/06/09
Mayer CM et al. – A sustained elevation of insulin levels diminishes neuronal insulin signaling through mTOR–S6K1–mediated IRS–1 serine phosphorylation, proteasomal degradation of IRS–1 and lysosomal degradation of the IR.
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